The Leader in Autologous Fibroblast Therapies

At the forefront of personalized biologics 

Castle Creek Biosciences, Inc., a clinical-stage cell and gene therapy company, is focused on developing and commercializing disease-modifying therapies for patients suffering from rare diseases for which there is a lack of available treatment options. Our approach to personalized biologics is distinctive based on our proprietary, autologous fibroblast technology platform. By extracting fibroblast cells from a patient’s own skin, we create localized treatments that are compatible with the unique biology of each patient and have the potential to address the underlying cause of disease.

Our Mission

To leverage the science behind our proprietary, autologous fibroblast technology platform and manufacturing experience to create transformative cell and gene therapies and improve the lives of patients suffering from rare diseases for which there are no disease-modifying treatments available.

Our Commitment to Life Science Innovation

Castle Creek Biosciences is a portfolio company of Paragon Biosciences.

Paragon is a global life science leader that creates, builds and funds innovative biology-based companies in three key areas: cell and gene therapy, adaptive biology and advanced biotechnology. The company’s current portfolio includes Castle Creek Biosciences, CiRC Biosciences, Emalex Biosciences, Evozyne, Harmony Biosciences, Qlarity Imaging, Skyline Biosciences, and a consistent flow of incubating companies created and supported by the replicable Paragon Innovation Capital™ model. Paragon stands at the intersection of human need, life science, and company creation. 

Our Inspiration

We are inspired by people who are impacted by rare diseases with limited or no therapeutic options. Our current focus is on dystrophic epidermolysis bullosa (DEB) and localized scleroderma, with the goal of expanding our platform to other therapeutic areas.